Anti-Calcium Sensing Receptor/CASR Antibody Picoband®

About this product

Boster Bio Anti-Calcium Sensing Receptor/CASR Antibody Picoband® catalog # PB9924. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9924

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH) -producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

Synonyms

Extracellular calcium-sensing receptor; CaSR; Parathyroid cell calcium-sensing receptor 1; PCaR1; CASR; GPRC2A, PCAR1

Gene Name

CASR

Gene ID

846

UniProt

P41180

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E. coli-derived human CASR recombinant protein (Position: Q926-S1078) . Human CASR shares 80.5% and 78.6% amino acid (aa) sequence identity with mouse and rat CASR, respectively.

Clonality

Polyclonal

Tissue Specificity

Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta. .

Applications

IHC, WB

Field of Research

Calcium Signaling, Cancer, Cofactors, Vitamins/Minerals, Cytoskeleton/ECM, Extracellular Matrix, G Protein Signaling, Growth Factors/Hormones, Lipid Signaling, Metabolism, Neuroscience, Neurotransmission, Pathways and Processes, Receptors / Channels, Signal Transduction, Signaling Pathway, Structures, Vitamins/Minerals

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system.

References & Citations

1. Coburn JW, Elangovan L, Goodman WG, Frazaõ JM (Dec 1999) . Calcium-sensing receptor and calcimimetic agents. Kidney International. Supplement 73: S52–8. 2. D'Souza-Li L (Aug 2006) . The calcium-sensing receptor and related diseases. Arquivos Brasileiros De Endocrinologia E Metabologia 50 (4) : 628–39. 3. Pidasheva S, Canaff L, Simonds WF, Marx SJ, Hendy GN (Jun 2005) . Impaired cotranslational processing of the calcium-sensing receptor due to signal peptide missense mutations in familial hypocalciuric hypercalcemia. Human Molecular Genetics 14 (12) : 1679–90.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

120674 MW

Observed Molecular Weight

150 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Extracellular calcium-sensing receptor

Subcellular Location

Cell membrane ; Multi-pass membrane protein .

Protein Name

Extracellular calcium-sensing receptor

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.