Anti-Calcitonin/CALCA Antibody

About this product

Boster Bio Anti-Calcitonin/CALCA Antibody catalog # PB9937. Tested in IHC applications. This antibody reacts with Mouse, Rat.

Specifications

Catalog number

PB9937

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Calcitonin, also known as CALCA, is a peptide hormone synthesized by the parafollicular cells of the thyroid. It is mapped to 11p15.2. Calcitonin belongs to the calcitonin-like protein family. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

Calcitonin gene-related peptide 1; Alpha-type CGRP; Calcitonin gene-related peptide I; CGRP-I; Calca; Calc

Gene Name

Calca

Gene ID

12310

UniProt

Q99JA0

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of mouse Calcitonin, different from the related human sequence by four amino acids, and identical to the related rat sequence.

Clonality

Polyclonal

Tissue Specificity

Detected in nerve cells of cerebrum, hippocampus and pons/midbrain in newborns, and only in nerve cells of pons/midbrain in adult. .

Applications

IHC

Field of Research

Cardiovascular, Contractility, Neuropeptides, Neuroscience, Neurotransmitter, Vasculature

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP (By similarity) . .

References & Citations

1. Alevizaki, M., Stevenson, J. C., Girgis, S. I., MacIntyre, I., Legon, S. Altered calcitonin gene in a young patient with osteoporosis.Brit. Med. J. 298: 1215-1216, 1989. Note: Retraction: Brit. Med. J. 299: 235 only, 1989. 2. Breimer, L. H., MacIntyre, I., Zaidi, M. Peptides from the calcitonin genes: molecular genetics, structure and function. Biochem. J. 255: 377-390, 1988. 3. Edbrooke, M. R., Parker, D., McVey, J. H., Riley, J. H., Sorenson, G. D., Pettengill, O. S., Craig, R. K. Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma. EMBO J. 4: 715-724, 1985.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

14065 MW

Observed Molecular Weight

75 kDa, 45 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Calcitonin gene-related peptide 1

Subcellular Location

Secreted.

Protein Name

Calcitonin gene-related peptide 1

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.