Anti-Glucose Transporter 5 GLUT5/SLC2A5 Antibody Picoband®

About this product

Boster Bio Anti-Glucose Transporter 5 GLUT5/SLC2A5 Antibody Picoband® catalog # PB9960. Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9960

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

SLC2A5, also known as GLUT5 (Glucose transporter 5), is a fructose transporter expressed on the apical border of enterocytes in the small intestine. The GLUT5 gene is located on chromosome 1. GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen. GLUT5 is also expressed in skeletal muscle, testis, kidney, fat tissue, and brain. Fructose malabsorption or Dietary Fructose Intolerance is a dietary disability of the small intestine, where the amount of fructose carrier in enterocytes is deficient.

Synonyms

Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5; SLC2A5; GLUT5

Gene Name

SLC2A5

Gene ID

6518

UniProt

P22732

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human SLC2A5, different from the related mouse and rat sequences by nine amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.

Applications

Flow Cytometry, IF, IHC, IHC-F, ICC, WB

Field of Research

Carbohydrate Metabolism, Channels, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism Of Carbohydrates, Pathways and Processes, Plasma Membrane, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter.

References & Citations

1. Burant, C. F., Takeda, J., Brot-Laroche, E., Bell, G. I., Davidson, N. O.Fructose transporter in human spermatozoa and small intestine is GLUT5.J. Biol. Chem. 267: 14523-14526, 1992. 2. Davidson, N. O., Hausman, A. M. L., Ifkovits, C. A., Buse, J. B., Gould, G. W., Burant, C. F., Bell, G. I.Human intestinal glucose transporter expression and localization of GLUT5.Am. J. Physiol. 262: C795-C800, 1992. 3. Kayano, T., Burant, C. F., Fukumoto, H., Gould, G. W., Fan, Y. S., Eddy, R. L., Byers, M. G., Shows, T. B., Seino, S., Bell, G. I.Human facilitative glucose transporters: isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6) .J. Biol. Chem. 265: 13276-13282, 1990.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

54974 MW

Observed Molecular Weight

55 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Solute carrier family 2, facilitated glucose transporter member 5

Subcellular Location

Apical cell membrane ; Multi- pass membrane protein . Membrane; Multi-pass membrane protein. Localized on the apical membrane of the small intestine and the proximal tubule of the kidney. .

Protein Name

Solute carrier family 2, facilitated glucose transporter member 5

Isotype

Rabbit IgG

Contents

243