Anti-Talin 2/TLN2 Antibody Picoband®

About this product

Boster Bio Anti-Talin 2/TLN2 Antibody Picoband® catalog # PB9961. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9961

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Talin 2 is a protein in humans that is encoded by the TLN2 gene. It belongs to the talin protein family. This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. Talin-2 is expressed at high levels in cardiac muscle and functions to provide linkages between the extracellular matrix and actin cytoskeleton at costamere structures to transduce force laterally.

Synonyms

Talin-2; TLN2; KIAA0320

Gene Name

TLN2

Gene ID

83660

UniProt

Q9Y4G6

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human Talin 2.

Clonality

Polyclonal

Tissue Specificity

Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.

Applications

IHC, WB

Field of Research

Actin Assembly, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity) . .

References & Citations

1. Entrez Gene: Talin 2. 2. Monkley SJ, Pritchard CA, Critchley DR (Sep 2001) . Analysis of the mammalian talin2 gene TLN2. Biochemical and Biophysical Research Communications 286 (5) : 880–5. 3. Praekelt U, Kopp PM, Rehm K, Linder S, Bate N, Patel B, Debrand E, Manso AM, Ross RS, Conti F, Zhang MZ, Harris RC, Zent R, Critchley DR, Monkley SJ (Mar 2012) . New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2. European Journal of Cell Biology 91 (3) : 180–91.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

271613 MW

Observed Molecular Weight

271 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Talin-2

Subcellular Location

Cell junction, focal adhesion. Cell junction, synapse. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Focal adhesion plaques and synapses.

Protein Name

Talin-2

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.