Anti-Plzf/ZBTB16 Antibody Picoband®

About this product

Boster Bio Anti-Plzf/ZBTB16 Antibody Picoband® catalog # PB9969. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9969

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene. This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL) . Alternate transcriptional splice variants have been characterized.

Synonyms

Zinc finger and BTB domain-containing protein 16; Promyelocytic leukemia zinc finger protein; Zinc finger protein 145; Zinc finger protein PLZF; ZBTB16; PLZF, ZNF145

Gene Name

ZBTB16

Gene ID

7704

UniProt

Q05516

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human Plzf recombinant protein (Position: M1-E165) .

Clonality

Polyclonal

Tissue Specificity

Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.

Applications

WB

Field of Research

Adaptive Immunity, Cell Type Markers, Immunology, Protein Phosphorylation, Signal Transduction, T Cells, Tags & Cell Markers, Tumor Associated, Tyrosine Kinases

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. .

References & Citations

1. Kovalovsky D, Uche OU, Eladad S, Hobbs RM, Yi W, Alonzo E, Chua K, Eidson M, et al. (2008) . The BTB-zinc finger transcriptional regulator, PLZF, controls the development of iNKT cell effector functions. Nature Immunology 9 (9) : 1055–64. 2. Savage AK, Constantinides MG, Han J, Picard D, Martin E, Li B, Lantz O, Bendelac A (2008) . The transcription factor PLZF (Zbtb16) s the effector program of the NKT cell lineage.Immunity 29 (3) : 391–403. 3. Zhang T, Xiong H, Kan LX, Zhang CK, Jiao XF, Fu G, Zhang QH, Lu L, et al. (1999) . Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene.Proceedings of the National Academy of Sciences of the United States of America 96 (20) : 11422–7.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

74274 MW

Observed Molecular Weight

74 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Zinc finger and BTB domain-containing protein 16

Subcellular Location

Nucleus.

Protein Name

Zinc finger and BTB domain-containing protein 16

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.