Anti-ALDH3A2 Antibody Picoband®

About this product

Boster Bio Anti-ALDH3A2 Antibody Picoband® catalog # PB9982. Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9982

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Fatty aldehyde dehydrogenase (or Long-chain-aldehyde dehydrogenase) is an aldehyde dehydrogenase enzyme that in human is encoded in the ALDH3A2 gene on chromosome 17. ALDH3A2 catalyzes the oxidation of long-chain aliphatic aldehydes into fatty acids. It is known to act on a variety of both saturated and unsaturated aliphatic aldehydes between 6 to 24 carbons in length, as well as dihydrophytal, a 20-carbon branched chain aldehyde. It requires NAD+ as a co-factor. The encoded enzyme is responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. ALD3H2 is expressed in the human liver and has been found to localize the microsome fraction inside the cell.

Synonyms

Fatty aldehyde dehydrogenase;1.2.1.3; Aldehyde dehydrogenase 10; Aldehyde dehydrogenase family 3 member A2; Microsomal aldehyde dehydrogenase; ALDH3A2; ALDH10, FALDH

Gene Name

ALDH3A2

Gene ID

224

UniProt

P51648

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human ALDH3A2 recombinant protein (Position: M1-Q100) . Human ALDH3A2 shares 78% amino acid (aa) sequence identity with both mouse and rat ALDH3A2.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis. Expressed at lower level in the spleen, fetal liver and lymph nodes. Isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all.

Applications

IHC, WB

Field of Research

Developmental Biology, Nervous System Development, Neuroscience, Organogenesis, Sensory System, Visual System

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. .

References & Citations

1. Kelson TL, Secor McVoy JR, Rizzo WB (1997) . Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization. Biochim. Biophys. Acta 1335 (1-2) : 99–110. 2. Rogers GR, Markova NG, De Laurenzi V, Rizzo WB, Compton JG (1997) . Genomic organization and expression of the human fatty aldehyde dehydrogenase gene (FALDH) . Genomics 39 (2) : 127–35.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

54848 MW

Observed Molecular Weight

55 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Fatty aldehyde dehydrogenase

Subcellular Location

Endoplasmic reticulum membrane ; Single-pass membrane protein ; Cytoplasmic side .

Protein Name

Fatty aldehyde dehydrogenase

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.