Anti-AKR1B1 Antibody Picoband®

About this product

Boster Bio Anti-AKR1B1 Antibody Picoband® catalog # PB10035. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB10035

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Aldo-keto reductase family 1, member B1 (aldose reductase), also known as AR, is an enzyme that in humans is encoded by the AKR1B1 gene. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number ofaldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol.

Synonyms

Aldose reductase; AR;1.1.1.21; Aldehyde reductase; Aldo-keto reductase family 1 member B1; AKR1B1; ALDR1

Gene Name

AKR1B1

Gene ID

231

UniProt

P15121

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E. coli-derived human AKR1B1 recombinant protein (Position: L228-F316) . Human AKR1B1 shares 87.5% amino acid (aa) sequence identity with both mouse and rat AKR1B1.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress. .

Applications

Flow Cytometry, IHC, WB

Field of Research

Cancer, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

References & Citations

1. Ferraretto A, Negri A, Giuliani A, et al. (1993) . Aldose reductase is involved in long-term adaptation of EUE cells to hyperosmotic stress.Biochim. Biophys. Acta 1175 (3) : 283–8. 2. Graham A, Heath P, Morten JE, Markham AF (March 1991) . The human aldose reductase gene maps to chromosome region 7q35. Hum. Genet. 86 (5) : 509–14.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

35853 MW

Observed Molecular Weight

36 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Aldose reductase

Subcellular Location

Cytoplasm.

Protein Name

Aldose reductase

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.