Anti-AKR1C1/C2 Antibody Picoband®

About this product

Boster Bio Anti-AKR1C1/C2 Antibody Picoband® catalog # PB10036. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB10036

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. And this gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.

Synonyms

Aldo-keto reductase family 1 member C2;1.-.-.-;3-alpha-HSD3; Chlordecone reductase homolog HAKRD; Dihydrodiol dehydrogenase 2; DD-2; DD2; Dihydrodiol dehydrogenase/bile acid-binding protein; DD/BABP; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase;1.3.1.20 ; Type III 3-alpha-hydroxysteroid dehydrogenase;1.1.1.357 ; AKR1C2; DDH2

Gene Name

AKR1C2

Gene ID

1645/1646

UniProt

P52895

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human AKR1C1/C2 recombinant protein (Position: M1-K123) .

Clonality

Polyclonal

Tissue Specificity

Expressed in fetal testes. Expressed in fetal and adult adrenal glands. .

Applications

Flow Cytometry, IF, ICC, WB

Field of Research

Cancer, Developmental Biology, Drug Metabolism, Endocrine Metabolism, Energy Metabolism, Energy Transfer Pathways, Growth Factors/Hormones, Hormone Biosynthesis, Lipid Metabolism, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Reproduction, Signal Transduction, Tumor Biomarkers

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol) . Has a high bile-binding ability. .

References & Citations

1. Ciaccio PJ, Tew KD (Jun 1994) . cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase. Biochimica et Biophysica Acta 1186 (1-2) : 129–32. 2. O'connor T, Ireland LS, Harrison DJ, Hayes JD (Oct 1999) . Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. The Biochemical Journal 343 (2) : 487–504.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

36735 MW

Observed Molecular Weight

37 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Aldo-keto reductase family 1 member C2

Subcellular Location

Cytoplasm .

Protein Name

Aldo-keto reductase family 1 member C1/C2

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.