Anti-CXCL16 Antibody Picoband®

About this product

Boster Bio Anti-CXCL16 Antibody Picoband® catalog # PB10054. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB10054

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

CXCL16, Chemokine (C-X-C motif) ligand 16, is a small cytokine belonging to the CXC chemokine family. Larger than other chemokines (with 254 amino acids), CXCL16 is composed of a CXC chemokine domain, a mucin-like stalk, a transmembrane domain and a cytoplasmic tail containing a potential tyrosine phosphorylation site that may bind SH2. By somatic cell hybrid analysis, the CXCL16 gene is mapped to 17p13, a locus separate from all other known chemokines. Chemotaxis assays found that CXCL16 induced a strong chemotactic response in activated CD8 T cells. In addition, CXCL16 induced calcium mobilization.

Synonyms

C-X-C motif chemokine 16; Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein; SR-PSOX; Small-inducible cytokine B16; Transmembrane chemokine CXCL16; CXCL16; SCYB16, SRPSOX; UNQ2759/PRO6714

Gene Name

CXCL16

Gene ID

58191

UniProt

Q9H2A7

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E. coli-derived human CXCL16 recombinant protein (Position: N30-A196) . Human CXCL16 shares 47% and 45.7% amino acid (aa) sequence identity with mouse and rat CXCL16, respectively.

Clonality

Polyclonal

Tissue Specificity

Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.

Applications

ELISA (Cap), WB

Field of Research

Chemokines, Immunology, Innate Immunity, Macrophage/Inflammation

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity) . Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. .

References & Citations

1. Matloubian, M., David, A., Engel, S., Ryan, J. E., Cyster, J. G.A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.Nature Immun. 1: 298-304, 2000. 2. Shimaoka, T., Kume, N., Minami, M., Hayashida, K., Kataoka, H., Kita, T., Yonehara, S.Molecular cloning of a novel scavenger receptor for oxidized low absorbance lipoprotein, SR-PSOX, on macrophages.J. Biol. Chem. 275: 40663-40666, 2000. 3. Wilbanks, A., Zondlo, S. C., Murphy, K., Mak, S., Soler, D., Langdon, P., Andrew, D. P., Wu, L., Briskin, M.Expression cloning of the STRL33/BONZO/TYMSTR ligand reveals elements of CC, CXC, CX3C chemokines.J. Immun. 166: 5145-5154, 2001.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

27579 MW

Observed Molecular Weight

35 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

C-X-C motif chemokine 16

Subcellular Location

Cell membrane ; Single-pass type I membrane protein . Secreted. Also exists as a soluble form.

Protein Name

C-X-C motif chemokine 16

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.