Anti-Synapsin II/SYN2 Antibody Picoband®

About this product

Boster Bio Anti-Synapsin II/SYN2 Antibody Picoband® catalog # PB10100. Tested in ICC/IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat, Pig. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB10100

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Synapsin II is the collective name for synapsin IIa and synapsin IIb, two nearly identical phosphoproteins in the synapsin family that in humans are encoded by the SYN2 gene. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite ion.

Synonyms

Synapsin-2; Synapsin II; SYN2

Gene Name

SYN2

Gene ID

6854

UniProt

Q92777

Host

Rabbit

Reactivity

Human, Mouse, Rat, Pig

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Synapsin II recombinant protein (Position: A497-D582) . Human Synapsin II shares 93.1% and 89.7% amino acid (aa) sequence identity with mouse and rat Synapsin II, respectively.

Clonality

Polyclonal

Tissue Specificity

Central and peripheral nervous systems.

Applications

WB, IHC, ICC/IF

Field of Research

Alzheimer's Disease, Neurodegenerative Disease, Neurology Process, Neuroscience

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity) . .

References & Citations

1. Entrez Gene: SYN2 synapsin II. 2. Li L, Chin LS, Greengard P, Copeland NG, Gilbert DJ, Jenkins NA (July 1995) . Localization of the synapsin II (SYN2) gene to human chromosome 3 and mouse chromosome 6. Genomics 28 (2) : 365–6.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

63 kDa

Observed Molecular Weight

55, 80 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Synapsin-2

Subcellular Location

Cell junction, synapse.

Protein Name

Synapsin-2

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.