Anti-HnRNP H/HNRNPH1 Antibody Picoband®

About this product

Boster Bio Anti-HnRNP H/HNRNPH1 Antibody Picoband® catalog # A07691. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A07691

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Heterogeneous nuclear ribonucleoprotein H is a protein that in humans is encoded by the HNRNPH1 gene. This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) . The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described.

Synonyms

Heterogeneous nuclear ribonucleoprotein H; hnRNP H; Heterogeneous nuclear ribonucleoprotein H, N-terminally processed; HNRNPH1; HNRPH, HNRPH1

Gene Name

HNRNPH1

Gene ID

3187

UniProt

P31943

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human HnRNP H, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed ubiquitously.

Applications

IF, IHC, ICC, WB, Flow Cytometry

Field of Research

Cardiovascular, Immunology, Innate Immunity, Macrophage/Inflammation, Platelets, Protein Phosphorylation, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly (RG) . .

References & Citations

1. Entrez Gene: HNRPH1 heterogeneous nuclear ribonucleoprotein H1 (H) . 2. Chou MY, Rooke N, Turck CW, Black DL (1999) . hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells.. Mol. Cell. Biol. 19 (1) : 69–77. 3. Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE (Jan 1996) . Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes. J Biol Chem. 270 (48) : 28780–9.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

49229 MW

Observed Molecular Weight

49 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Heterogeneous nuclear ribonucleoprotein H

Subcellular Location

Nucleus, nucleoplasm.

Protein Name

Heterogeneous nuclear ribonucleoprotein H

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.