Anti-ATTY/TAT Antibody Picoband®

About this product

Boster Bio Anti-ATTY/TAT Antibody Picoband® catalog # A00622. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00622

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked.

Synonyms

Tyrosine aminotransferase; TAT;2.6.1.5; L-tyrosine:2-oxoglutarate aminotransferase; TAT

Gene Name

TAT

Gene ID

6898

UniProt

P17735

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human ATTY, different from the related mouse and rat sequences by two amino acids.

Clonality

Polyclonal

Applications

WB

Field of Research

Antiviral Signaling,2339, Epigenetics and Nuclear Signaling, Immune System Diseases, Immunology, Microbiology

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro) . Has much lower affinity and transaminase activity towards phenylalanine. .

References & Citations

1. Natt E, Kida K, Odievre M, Di Rocco M, Scherer G (October 1992) . Point mutations in the tyrosine aminotransferase gene in tyrosinemia type II. Proc. Natl. Acad. Sci. U.S.A. 89 (19) : 9297–301. 2. Rettenmeier R, Natt E, Zentgraf H, Scherer G (July 1990) . Isolation and characterization of the human tyrosine aminotransferase gene. Nucleic Acids Res. 18 (13) : 3853–61.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

50399 MW

Observed Molecular Weight

42 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Tyrosine aminotransferase

Subcellular Location

Cell membrane.

Protein Name

Tyrosine aminotransferase

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.