Anti-Angiotensinogen/AGT Antibody Picoband®

About this product

Boster Bio Anti-Angiotensinogen/AGT Antibody Picoband® catalog # A02103-1. Tested in IHC, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02103-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

AGT (ANGIOTENSINOGEN), also called SERPINA8, is an α -2-globulin that is produced constitutively and released into the circulation mainly by the liver. ATG is a member of the serpin family, although it is not known to inhibit other enzymes, unlike most serpins. Angiotensinogen is also known as renin substrate. The AGT gene is mapped on 1q42.2. And the human angiotensinogen gene contains 5 exons. The expression of AGT and enzymes required for its conversion to angiotensin II in human adipose tissue. Mutations in this AGT gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Synonyms

Angiotensinogen; Serpin A8; Angiotensin-1; Angiotensin 1-10; Angiotensin I; Ang I; Angiotensin-2; Angiotensin 1-8; Angiotensin II; Ang II; Angiotensin-3; Angiotensin 2-8; Angiotensin III; Ang III; Des-Asp[1]-angiotensin II; Angiotensin-4; Angiotensin 3-8; Angiotensin IV; Ang IV; Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4; Agt; Serpina8

Gene Name

Agt

Gene ID

183

UniProt

P11859

Host

Rabbit

Reactivity

Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived mouse Angiotensinogen recombinant protein (Position: D25-A115) . Mouse Angiotensinogen shares 62.2% and 87.9% amino acid (aa) sequence identity with human and rat Angiotensinogen, respectively.

Clonality

Polyclonal

Tissue Specificity

Expressed by the liver and secreted in plasma.

Applications

IHC, WB

Field of Research

Cardiovascular, G Protein Signaling, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.

References & Citations

1. Abonia, J. P., Abel, K. J., Eddy, R. L., Elliott, R. W., Chapman, V. M., Shows, T. B., Gross, K. W. Linkage of Agt and Actsk-1 to distal mouse chromosome 8 loci: a new conserved linkage. Mammalian Genome 4: 25-32, 1993. 2. Arakawa, K., Minohara, A., Yamada, J., Nakamura, M. Enzymatic degradation and electrophoresis of human angiotensin I. Biochim. Biophys. Acta 168: 106-112, 1968. 3. Basso N, Terragno NA (December 2001) . History about the discovery of the renin-angiotensin system. Hypertension 38 (6) : 1246–9.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

51990 MW

Observed Molecular Weight

53-55 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Angiotensinogen

Subcellular Location

Secreted.

Protein Name

Angiotensinogen

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.