Anti-Hydrogen Potassium ATPase Beta/ATP4B Antibody Picoband®

About this product

Boster Bio Anti-Hydrogen Potassium ATPase Beta/ATP4B Antibody Picoband® catalog # A08719-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A08719-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

This gene encodes the beta subunit of the gastric H+, K+-ATPase. The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H (+) and K (+) ions across the plasma membrane. It is also responsible for gastric acid secretion.

Synonyms

Potassium-transporting ATPase subunit beta; Gastric H (+) /K (+) ATPase subunit beta; Proton pump beta chain; ATP4B

Gene Name

ATP4B

Gene ID

496

UniProt

P51164

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human ATP4B, different from the related mouse and rat sequences by five amino acids.

Clonality

Polyclonal

Applications

WB

Field of Research

ATPases, Cancer, Cofactors, Vitamins/Minerals, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction, Vitamins/Minerals

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity. .

References & Citations

1. Canfield, V. A., Okamoto, C. T., Chow, D., Dorfman, J., Gros, P., Forte, J. G., Levenson, R. Cloning of the H, K-ATPase beta subunit: tissue-specific expression, chromosomal assignment, and relationship to Na, K-ATPase beta subunits. J. Biol. Chem. 265: 19878-19884, 1990. 2. Reuben, M. A., Lasater, L. S., Sachs, G. Characterization of a beta subunit of the gastric H (+) /K (+) -transporting ATPase. Proc. Nat. Acad. Sci. 87: 6767-6771, 1990. 3. Song, I., Brown, D. R., Yamada, T., Trent, J. M. Mapping of the gene encoding the beta-subunit of H (+), K (+) -ATPase to human chromosome 13q34 by fluorescence in situ hybridization. Genomics 14: 1114-1115, 1992.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

33367 MW

Observed Molecular Weight

60 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Potassium-transporting ATPase subunit beta

Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Protein Name

Potassium-transporting ATPase subunit beta

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.