Anti-IFNGR1 Antibody Picoband®

About this product

Boster Bio Anti-IFNGR1 Antibody Picoband® catalog # A01716-1. Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01716-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interferon gamma receptor 1 (IFNGR1), also known as CD119 (Cluster of Differentiation 119), is a protein that in humans is encoded by the IFNGR1 gene. This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.

Synonyms

Interferon gamma receptor 1; IFN-gamma receptor 1; IFN-gamma-R1; CDw119; CD119; IFNGR1

Gene Name

IFNGR1

Gene ID

3459

UniProt

P15260

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human IFNGR1, different from the related mouse sequence by seventeen amino acids.

Clonality

Polyclonal

Tissue Specificity

Liver and small intestine. Also found in ovary, testis and kidney.

Applications

Flow Cytometry, IHC, ICC, WB

Field of Research

Antiviral Signaling, Cytokines, Hematopoietic Progenitors, Host-Virus Interaction, Immune System Diseases, Immunology, Innate Immunity, Interferons, Interspecies Interaction, Lymphoid, Macrophage/Inflammation, Microbiology, Myeloid, Stem Cells, Surface Molecules, T Lymphocytic Lineage

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460) . Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114) . .

References & Citations

1. Entrez Gene: IFNGR1 interferon gamma receptor 1. 2. Aguet M, Dembić Z, Merlin G (Oct 1988) . Molecular cloning and expression of the human interferon-gamma receptor. Cell. 55 (2) : 273–80. 3. Novick D, Orchansky P, Revel M, Rubinstein M (Jun 1987) . The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies. The Journal of Biological Chemistry. 262 (18) : 8483–7.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

54405 MW

Observed Molecular Weight

95 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Interferon gamma receptor 1

Subcellular Location

Cell membrane ; Single-pass type I membrane protein .

Protein Name

Interferon gamma receptor 1

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.