Anti-MC1 Receptor/MC1R Antibody Picoband®

About this product

Boster Bio Anti-MC1 Receptor/MC1R Antibody Picoband® catalog # A00855-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00855-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

The melanocortin 1 receptor (MC1R), mapped to 16q24.3, is also known as MSHR. This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH) . The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

Synonyms

Melanocyte-stimulating hormone receptor; MSH-R; Melanocortin receptor 1; MC1-R; MC1R; MSHR

Gene Name

MC1R

Gene ID

4157

UniProt

Q01726

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human MC1 Receptor.

Clonality

Polyclonal

Tissue Specificity

Melanocytes and corticoadrenal tissue.

Applications

WB

Field of Research

Endocrine Metabolism, Hormone Biosynthesis, Metabolism, More Gpcr, Neuroscience, Neurotransmission, Pathways and Processes, Receptors / Channels

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

References & Citations

1. Aoki H, Moro O (2002) . Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R) . Life Sci. 71 (18) : 2171–9. 2. Mogil JS, Ritchie J, Smith SB, Strasburg K, Kaplan L, Wallace MR, Romberg RR, Bijl H, Sarton EY, Fillingim RB, Dahan A (2005) .Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans. J. Med. Genet. 42 (7) : 583–7. 3. Robbins LS, Nadeau JH, Johnson KR, Kelly MA, Roselli-Rehfuss L, Baack E, Mountjoy KG, Cone RD (1993) . Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function.. Cell. 72 (6) : 827–834.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

34706 MW

Observed Molecular Weight

35 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Melanocyte-stimulating hormone receptor

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Name

Melanocyte-stimulating hormone receptor

Isotype

Rabbit IgG

Contents

243