Anti-MMP11 Antibody Picoband®

About this product

Boster Bio Anti-MMP11 Antibody Picoband® catalog # A04490-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A04490-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Stromelysin-3 (SL-3) also known as matrix metalloproteinase-11 (MMP-11) is an enzyme that in humans is encoded by the MMP11 gene. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.

Synonyms

Stromelysin-3; SL-3; ST3;3.4.24.-; Matrix metalloproteinase-11; MMP-11; MMP11; STMY3

Gene Name

MMP11

Gene ID

4320

UniProt

P24347

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human MMP11, different from the related mouse and rat sequences by three amino acids.

Clonality

Polyclonal

Tissue Specificity

Specifically expressed in stromal cells of breast carcinomas.

Applications

IHC, WB

Field of Research

Angiogenesis, Cancer, Cardiovascular, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

May play an important role in the progression of epithelial malignancies.

References & Citations

1. Entrez Gene: MMP11 matrix metallopeptidase 11 (stromelysin 3) . 2. Anglard P, Melot T, Guerin E, Thomas G, Basset P (Oct 1995) . Structure and promoter characterization of the human stromelysin-3 gene. J Biol Chem. 270 (35) : 20337–44. 3. Levy A, Zucman J, Delattre O, Mattei MG, Rio MC, Basset P (Aug 1992) . Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22. Genomics. 13 (3) : 881–3.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

54590 MW

Observed Molecular Weight

55 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Stromelysin-3

Subcellular Location

Secreted, extracellular space, extracellular matrix .

Protein Name

Stromelysin-3

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.