Anti-TSG6/TNFAIP6 Antibody Picoband®

About this product

Boster Bio Anti-TSG6/TNFAIP6 Antibody Picoband® catalog # A03433-1. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A03433-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tumor necrosis factor-inducible gene 6 protein, also known as TSG-6, is a protein that in humans is encoded by the TNFAIP6 gene. The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.

Synonyms

Tumor necrosis factor-inducible gene 6 protein; Hyaluronate-binding protein; TNF-stimulated gene 6 protein; TSG-6; Tumor necrosis factor alpha-induced protein 6; TNF alpha-induced protein 6; TNFAIP6; TSG6

Gene Name

TNFAIP6

Gene ID

7130

UniProt

P98066

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human TSG6, different from the related mouse sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Found in the synovial fluid of patients with rheumatoid arthritis. .

Applications

WB

Field of Research

Cancer, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Immunology, Innate Immunity, Invasion/Microenvironment, Macrophage/Inflammation, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.

References & Citations

1. Entrez Gene: TNFAIP6 tumor necrosis factor, alpha-induced protein 6. 2. Lee TH, Klampfer L, Shows TB, Vilcek J (March 1993) . Transcriptional regulation of TSG6, a tumor necrosis factor- and interleukin-1-inducible primary response gene coding for a secreted hyaluronan-binding protein. J. Biol. Chem. 268 (9) : 6154–60. 3. Milner CM, Day AJ (2004) . TSG-6: a multifunctional protein associated with inflammation.. J. Cell. Sci. 116 (Pt 10) : 1863–73.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

31203 MW

Observed Molecular Weight

31 kDa.

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Tumor necrosis factor-inducible gene 6 protein

Subcellular Location

Late endosome membrane. Peripheral membrane protein. Prevacuolar compartment membrane.

Protein Name

Tumor necrosis factor-inducible gene 6 protein

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.