Anti-TREML1 Antibody Picoband®

About this product

Boster Bio Anti-TREML1 Antibody Picoband® catalog # A07682-2. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A07682-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Trem-like transcript 1 protein is a protein that in humans is encoded by the TREML1 gene. The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.

Synonyms

Trem-like transcript 1 protein; TLT-1; Triggering receptor expressed on myeloid cells-like protein 1; TREML1; TLT1; UNQ1825/PRO3438

Gene Name

TREML1

Gene ID

340205

UniProt

Q86YW5

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human TREML1 recombinant protein (Position: Q16-P162) . Human TREML1 shares 69.3% amino acid (aa) sequence identity with mouse TREML1.

Clonality

Polyclonal

Tissue Specificity

Detected in platelets, monocytic leukemia and in T-cell leukemia. .

Applications

ELISA, WB

Field of Research

Cardiovascular, Immunology, Innate Immunity, Macrophage/Inflammation, Platelets, Protein Phosphorylation, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Cell surface receptor that may play a role in the innate and adaptive immune response. .

References & Citations

1. Entrez Gene: TREML1 triggering receptor expressed on myeloid cells-like 1. 2. Allcock RJ, Barrow AD, Forbes S, Beck S, Trowsdale J (Mar 2003) . The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur J Immunol. 33 (2) : 567–77. 3. Washington AV, Quigley L, McVicar DW (Nov 2002) . Initial characterization of TREM-like transcript (TLT) -1: a putative inhibitory receptor within the TREM cluster. Blood. 100 (10) : 3822–4.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

32679 MW

Observed Molecular Weight

33 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Trem-like transcript 1 protein

Subcellular Location

Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151) . Transported to the cell surface after stimulation by thrombin (PubMed:15100151) . Soluble fragments can be released into the serum by proteolysis (PubMed:16505478) .

Protein Name

Trem-like transcript 1 protein

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.