Anti-AKR1B10 Antibody Picoband®

About this product

Boster Bio Anti-AKR1B10 Antibody Picoband® catalog # A02976. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02976

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Aldo-keto reductase family 1 member B10 is an enzyme that in humans is encoded by the AKR1B10 gene. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.

Synonyms

Aldo-keto reductase family 1 member B10;1.1.1.-; ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase; AKR1B10; AKR1B11

Gene Name

AKR1B10

Gene ID

57016

UniProt

O60218

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human AKR1B10.

Clonality

Polyclonal

Tissue Specificity

Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.

Applications

IF, IHC, ICC, WB

Field of Research

Cancer, Drug Metabolism, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction, Tumor Biomarkers

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro) . May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. .

References & Citations

1. Cao D, Fan ST, Chung SS (Jun 1998) . Identification and characterization of a novel human aldose reductase-like gene. J Biol Chem. 273 (19) : 11429–35. 2. Hyndman DJ, Flynn TG (Oct 1998) . Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family. Biochim Biophys Acta. 1399 (2–3) : 198–202.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

36020 MW

Observed Molecular Weight

36 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Aldo-keto reductase family 1 member B10

Subcellular Location

Lysosome . Secreted . Secreted through a lysosome-mediated non-classical pathway.

Protein Name

Aldo-keto reductase family 1 member B10

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.