Anti-AMH Antibody Picoband®

About this product

Boster Bio Anti-AMH Antibody Picoband® catalog # A00763. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00763

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Anti-Müllerian hormone (AMH), also known as MIF or MIS, is a protein that in humans is encoded by the AMH gene. It is a hormone that inhibits the development of the Müllerian ducts (paramesonephric ducts) in the male embryo. Expression of AMH is activated by SOX9 in the male Sertoli cells and causes the irreversible regression of the Müllerian ducts. Because AMH expression is critical to sex differentiation at a specific time during fetal development, it appears to be tightly regulated by SF1, GATA factors, DAX1 and FSH. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome.

Synonyms

Muellerian-inhibiting factor; Anti-Muellerian hormone; AMH; Muellerian-inhibiting substance; MIS; AMH; MIF

Gene Name

AMH

Gene ID

268

UniProt

P03971

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human AMH recombinant protein (Position: A75-E141) . Human AMH shares 66.7% amino acid (aa) sequence identity with both mouse and rat AMH.

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in lung and at lower level in kidney. Expressed in macrophages but not in vascular smooth muscle cells.

Applications

WB

Field of Research

Developmental Biology, Growth Factors/Hormones, Reproduction, Secreted, Signal Transduction, Signaling Pathways, Stem Cells, TGF Beta

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.

References & Citations

1. Behringer RR (1994) . The in vivo roles of müllerian-inhibiting substance. Current Topics in Developmental Biology. Current Topics in Developmental Biology. 29: 171–87. 2. Cate RL, Mattaliano RJ, Hession C, Tizard R, Farber NM, Cheung A, Ninfa EG, Frey AZ, Gash DJ, Chow EP (Jun 1986) . Isolation of the bovine and human genes for Müllerian inhibiting substance and expression of the human gene in animal cells. Cell. 45 (5) : 685–98. 3. Taguchi O, Cunha GR, Lawrence WD, Robboy SJ (Dec 1984) . Timing and irreversibility of Müllerian duct inhibition in the embryonic reproductive tract of the human male. Developmental Biology. 106 (2) : 394–8.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

59195 MW

Observed Molecular Weight

65 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Muellerian-inhibiting factor

Subcellular Location

Secreted.

Protein Name

Muellerian-inhibiting factor

Isotype

Rabbit IgG

Contents

243