Anti-IL-2/IL2 Antibody Picoband®

About this product

Boster Bio Anti-IL-2/IL2 Antibody Picoband® catalog # A00387-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00387-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

IL-2, Interleukin-2, formerly referred to as T-cell growth factor, is a powerfully immunoregulatory lymphokine that is produced by lectin-or antigen-activated T cells. In situ hybridization, the IL-2 gene is assigned to 4q26-q28. IL2 can act as a growth hormone for both B and T lymphocytes. It is useful in the study of the molecular nature of T-cell differentiation and, like interferons, augments natural killer cell activity.

Synonyms

Interleukin-2; IL-2; T-cell growth factor; TCGF; Aldesleukin; IL2

Gene Name

IL2

Gene ID

3558

UniProt

P60568

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human IL-2 recombinant protein (Position: A21-T153) . Human IL-2 shares 57.5% and 66.4% amino acid (aa) sequence identity with mouse and rat IL-2, respectively.

Clonality

Polyclonal

Tissue Specificity

Expressed in fetal brain.

Applications

ELISA, IHC, WB

Field of Research

Adaptive Immunity, Cell Type Markers, Cytokines, Immunology, Innate Immunity, Interleukins, T Cells

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells.

References & Citations

1. Lowenthal, J. W., Zubler, R. H., Nabholz, M., MacDonald, H. R.Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes.Nature 315: 669-672, 1985. 2. Seigel, L. J., Harper, M. E., Wong-Staal, F., Gallo, R. C., Nash, W. G., O'Brien, S. J.Gene for T-cell growth factor: location on human chromosome 4q and feline chromosome B1.Science 223: 175-178, 1984. 3. Weinberg, K., Parkman, R.Severe combined immunodeficiency due to a specific defect in the production of interleukin-2.New Eng. J. Med. 322: 1718-1723, 1990.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

18 kDa

Observed Molecular Weight

15 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Interleukin-2

Subcellular Location

Secreted.

Protein Name

Interleukin-2

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.