Anti-TLR2 Antibody Picoband®

About this product

Boster Bio Anti-TLR2 Antibody Picoband® catalog # A00131. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00131

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Toll-like receptor 2, also known as TLR-2, is a protein that in humans is encoded by the TLR2 gene. It has also been designated as CD282 (cluster of differentiation 282) . TLR-2 plays a role in the immune system. And TLR-2 is a membrane protein, a receptor, which is expressed on the surface of certain cells and recognizes foreign substances and passes on appropriate signals to the cells of the immune system. TLR2 expresses as 4- and 4.4-kb mRNAs in heart, brain, and muscle.

Synonyms

Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD282; TLR2; TIL4

Gene Name

TLR2

Gene ID

7097

UniProt

O60603

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human TLR2 recombinant protein (Position: H610-S784) . Human TLR2 shares 87.4% amino acid (aa) sequence identity with mouse TLR2.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.

Applications

WB

Field of Research

Adapters, Atherosclerosis, Cardiovascular, Defensin, Human Protein, Immunoglobulins, Immunology, Innate Immunity, Macrophage/Inflammation, Microbiology, Protein, Receptors, Signal Transduction, TLR Signaling, Transmembrane, Vascular Inflammation

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.

References & Citations

1. Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF (January 1998) . A family of human receptors structurally related to Drosophila Toll. Proc. Natl. Acad.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

89838 MW

Observed Molecular Weight

105 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Toll-like receptor 2

Subcellular Location

Membrane ; Single-pass type I membrane protein .

Protein Name

Toll-like receptor 2

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.