Anti-TMEM240 Antibody Picoband®

About this product

Boster Bio Anti-TMEM240 Antibody Picoband® catalog # A14889. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A14889

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

TMEM240 is a small, highly conserved transmembrane protein expressed in brain. The TMEM240 gene maps to chromosome 1p36.33. This gene encodes a transmembrane-domain containing protein found in the brain and cerebellum. Mutations in this gene result in spinocerebellar ataxia 21.

Synonyms

Transmembrane protein 240; TMEM240; C1orf70

Gene Name

TMEM240

Gene ID

339453

UniProt

Q5SV17

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human TMEM240 recombinant protein (Position: M1-L173) . Human TMEM240 shares 97.7% amino acid (aa) sequence identity with mouse TMEM240.

Clonality

Polyclonal

Tissue Specificity

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Applications

WB

Field of Research

Cell Biology

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

References & Citations

1. Delplanque, J., Devos, D., Huin, V., Genet, A., Sand, O., Moreau, C., Goizet, C., Charles, P., Anheim, M., Monin, M. L., Buee, L., Destee, A., and 9 others. TMEM240 mutations cause spinocerebellar ataxia 21 with mental retardation and severe cognitive impairment. Brain 137: 2657-2663, 2014. the TMEM240 gene maps to chromosome 1p36.33. 2. Devos, D., Schraen-Maschke, S., Vuillaume, I., Dujardin, K., Naze, P., Willoteaux, C., Destee, A., Sablonniere, B. Clinical features and genetic analysis of a new form of spinocerebellar ataxia. Neurology 56: 234-238, 2001.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

19908 MW

Observed Molecular Weight

19 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Transmembrane protein 240

Subcellular Location

Cell junction, synapse . Cell membrane ; Multi-pass membrane protein .

Protein Name

Transmembrane protein 240

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.