Anti-C19orf80/ANGPTL8 Antibody Picoband®

About this product

Boster Bio Anti-C19orf80/ANGPTL8 Antibody Picoband® catalog # A02471. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02471

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

ANGPTL8 (also known as lipasin, originally Betatrophin) is a protein that in humans is encoded by the C19orf80 gene. The gene for betatrophin lies on mouse chromosome 9 (gene symbol: Gm6484) and on human chromosome 19 (gene symbol: C19orf80) . The encoded 22 kDa protein contains an N-terminal secretion signal and two coiled-coil domains and is a member of the angiopoietin-like (ANGPTL) protein family. However, in contrast to other ANGPTL proteins, betatrophin lacks the C-terminal fibrinogen-like domain, and therefore it is an atypical member of the ANGPTL family. It shares with Angptl4 and Angptl3 the ability to inhibit the enzyme Lipoprotein lipase (LPL), and its hepatic overexpression causes elevation of circulating Triglyceride levels in mice. In mice betatrophin is secreted by the liver. It was hoped that betatrophin or its homolog in humans may provide an effective treatment for type 2 diabetes and perhaps even type I diabetes.

Synonyms

Angiopoietin-like protein 8 ; Betatrophin ; Lipasin ; Refeeding-induced fat and liver protein ; ANGPTL8 ; C19orf80, RIFL ; UNQ599/PRO1185

Gene Name

ANGPTL8

Gene ID

55908

UniProt

Q6UXH0

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human C19orf80 recombinant protein (Position: A22-A198) . Human C19orf80 shares 74% amino acid (aa) sequence identity with mouse C19orf80.

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in liver. Also expressed in adipose tissues. .

Applications

WB

Field of Research

Cell Biology

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577) . May be involved in the metabolic transition between fasting and refeeding: required to fatty acids to adipose tissue for storage in the fed state (By similarity) . .

References & Citations

1. Fu Z, Yao F, Abou-Samra AB, Zhang R (Jan 2013) . Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family. Biochemical and Biophysical Research Communications. 430 (3) : 1126–31. 2. Yi P, Park JS, Melton DA (May 2013) . Betatrophin: a hormone that controls pancreatic β cell proliferation. Cell. 153 (4) : 747–58. 3. Zhang R (Aug 2012) . Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. Biochemical and Biophysical Research Communications. 424 (4) : 786–92.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

22105 MW

Observed Molecular Weight

22 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Angiopoietin-like protein 8

Subcellular Location

Secreted .

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.