Anti-CCR1 Antibody Picoband®

About this product

Boster Bio Anti-CCR1 Antibody Picoband® catalog # A01896-1. Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01896-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1) . Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite.

Synonyms

C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; CD191; Ccr1; Cmkbr1

Gene Name

Ccr1

Gene ID

12768

UniProt

P51675

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived mouse CCR1 recombinant protein (Position: A168-T339) . Mouse CCR1 shares 76.5% amino acid (aa) sequence identity with human CCR1.

Clonality

Polyclonal

Tissue Specificity

Detected in the heart, spleen, lung, peritoneal exudate cells and leukocytes.

Applications

WB

Field of Research

Chemokines, Immunology, Innate Immunity

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

References & Citations

1. Entrez Gene: CCR1 chemokine (C-C motif) receptor 1. 2. Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ (Mar 1993) . Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell 72 (3) : 415–25.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

40895 MW

Observed Molecular Weight

48 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

C-C chemokine receptor type 1

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.