Anti-FMN1 Antibody Picoband®

About this product

Boster Bio Anti-FMN1 Antibody Picoband® catalog # A07520. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A07520

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Formins, such as FMN1, are actin-nucleating proteins involved in cell polarity, cytokinesis, cell migration, and transcriptional activity. This FMN1 gene belongs to the formin homology family and encodes a protein that has a role in the formation of adherens junction and the polymerization of linear actin cables. The homologous gene in mouse is associated with limb deformity. Alternatively spliced transcript variants have been found for this gene.

Synonyms

Formin-1; Limb deformity protein homolog; FMN1; FMN, LD

Gene Name

FMN1

Gene ID

342184

UniProt

Q68DA7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human FMN1 recombinant protein (Position: N1195-N1419) . Human FMN1 shares 93.8% amino acid (aa) sequence identity with mouse FMN1.

Clonality

Polyclonal

Tissue Specificity

Expressed ubiquitously.

Applications

IHC, WB

Field of Research

Actin Assembly, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Plays a role in the formation of adherens junction and the polymerization of linear actin cables. .

References & Citations

1. Chalkia D, Nikolaidis N, Makalowski W, Klein J, Nei M (December 2008) . Origins and evolution of the forminmultigene family that is involved in the formation of actin filaments. Molecular Biology and Evolution. 25 (12) : 2717–33. 2. Evangelista M, Zigmond S, Boone C (July 2003) . Formins: signaling effectors for assembly and polarization of actin filaments. Journal of Cell Science. 116 (Pt 13) : 2603–11. 3. Goode BL, Eck MJ (2007) . Mechanism and function of formins in the control of actin assembly. Annual Review of Biochemistry. 76: 593–627.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

157578 MW

Observed Molecular Weight

158 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Formin-1

Subcellular Location

Nucleus . Cytoplasm . Cell junction, adherens junction . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Localization to the adherens junctions is alpha-catenin-dependent. Also localizes to F-actin bundles originating from adherens junctions and to microtubules (By similarity) . .

Protein Name

BAG family molecular chaperone regulator 5

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.