Anti-IL-16/Il16 Antibody Picoband®

About this product

Boster Bio Anti-IL-16/Il16 Antibody Picoband® catalog # A01635. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01635

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin 16 (IL-16) is a cytokine that released by a variety of cells (including lymphocytes and some epithelial cells) that has been characterized as a chemoattractant for certain immune cells expressing the cell surface molecule CD4. It is mapped to 15q25.1. IL-16 was originally described as a factor that could attract activated T cells in humans. It was previously called lymphocyte chemoattractant factor (LCF), and the augmentation of IL16 stimulation by CCR5 plays a role in regulation of Th1 cell recruitment and activation at sites of inflammation.

Synonyms

Pro-interleukin-16; Interleukin-16; IL-16; Lymphocyte chemoattractant factor; LCF; Il16

Gene Name

Il16

Gene ID

16170

UniProt

O54824

Host

Rabbit

Reactivity

Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived mouse IL-16 recombinant protein (Position: S1205-S1322) . Mouse IL-16 shares 86.7% amino acid (aa) sequence identity with human IL-16.

Clonality

Polyclonal

Tissue Specificity

Isoform 1 is expressed in neurons of the cerebellum and hippocampus. Isoform 2 is expressed in thymus, spleen and lung.

Applications

ELISA, IHC, WB

Field of Research

Cytokines, Immunology, Innate Immunity, Interleukins

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.

References & Citations

1. Bannert, N., Kurth, R., Baier, M. The gene encoding mouse interleukin-16 consists of seven exons and maps to Chromosome 7 D2-D3. Immunogenetics 49: 704-706, 1999. 2. Cruikshank W, Center DM (1982) . Modulation of lymphocyte migration by human lymphokines. II. Purification of a lymphotactic factor (LCF) .J. Immunol. 128 (6) : 2569–74. 3. Drwinga, H. L., Toji, L. H., Kim, C. H., Greene, A. E., Mulivor, R. A. NIGMS human/rodent somatic cell hybrid mapping panels 1 and 2. Genomics 16: 311-314, 1993. 4. Hudson, T. J., Stein, L. D., Gerety, S. S., Ma, J., Castle, A. B., Silva, J., Slonim, D. K., Baptista, R., Kruglyak, L., Xu, S. H., Hu, X., Colbert, A. M. E., and 39 others. An STS-based map of the human genome. Science 270: 1945-1954, 1995.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

141435 MW

Observed Molecular Weight

18 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Pro-interleukin-16

Subcellular Location

Secreted .

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.