Anti-L17A Receptor/IL17RA Antibody Picoband®

About this product

Boster Bio Anti-L17A Receptor/IL17RA Antibody Picoband® catalog # A01311-2. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01311-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene. The IL17R gene is mapped to 22q11.22-q11.23 by radiation hybrid analysis. Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis.

Synonyms

Interleukin-17 receptor A; IL-17 receptor A; IL-17RA; CDw217; CD217; IL17RA; IL17R

Gene Name

IL17RA

Gene ID

23765

UniProt

Q96F46

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human IL17RA recombinant protein (Position: K53-Q284) . Human IL17RA shares 74.1% amino acid (aa) sequence identity with mouse IL17RA.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. .

Applications

WB, ELISA

Field of Research

Cytokines, Immunology, Innate Immunity, Interleukins, Macrophage/Inflammation

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for IL17A (PubMed:17911633, PubMed:9367539) . Receptor for IL17F (PubMed:19838198, PubMed:17911633) . Binds to IL17A with higher affinity than to IL17F (PubMed:17911633) . Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495) . Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971) . Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848) . Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971) . .

References & Citations

1. Entrez Gene: IL17RA interleukin 17 receptor A. 2. Yao, Z., Spriggs, M. K., Derry, J. M. J., Strockbine, L., Park, L. S., VandenBos, T., Zappone, J., Painter, S. L., Armitage, R. J. Molecular characterization of the human interleukin (IL) -17 receptor. Cytokine 9: 794-800, 1997. 3. Yao, Z., Fanslow, W. C., Seldin, M. F., Rousseau, A.-M., Painter, S. L., Comeau, M. R., Cohen, J. I., Spriggs, M. K. Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 3: 811-821, 1995.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

96122 MW

Observed Molecular Weight

120-150 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Interleukin-17 receptor A

Subcellular Location

Isoform 1: Cell membrane ; Single-pass type I membrane protein .

Protein Name

Peptidyl-prolyl cis-trans isomerase A

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.