Anti-PREB Antibody Picoband®

About this product

Boster Bio Anti-PREB Antibody Picoband® catalog # A04946. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A04946

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Prolactin regulatory element-binding protein is a protein that in humans is encoded by the PREB gene. This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand.

Synonyms

Prolactin regulatory element-binding protein; Mammalian guanine nucleotide exchange factor mSec12; PREB; SEC12

Gene Name

PREB

Gene ID

10113

UniProt

Q9HCU5

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human PREB recombinant protein (Position: K42-N236) . Human PREB shares 87.7% amino acid (aa) sequence identity with both mouse and rat PREB.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. .

Applications

WB

Field of Research

Epigenetics and Nuclear Signaling, Transcription

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitement of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER. .

References & Citations

1. Edgar AJ (Jul 2003) . The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12. BMC Genomics. 4: 18. 2. Fliss MS, Hinkle PM, Bancroft C (May 1999) . Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity. MolEndocrinol. 13 (4) : 644–657.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

45468 MW

Observed Molecular Weight

45 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Prolactin regulatory element-binding protein

Subcellular Location

Endoplasmic reticulum membrane ; Single-pass membrane protein . Nucleus . Concentrates at endoplasmic reticulum exit sites. .

Protein Name

Vesicular acetylcholine transporter

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.