Anti-Syndecan-1/SDC1 Antibody Picoband®

About this product

Boster Bio Anti-Syndecan-1/SDC1 Antibody Picoband® catalog # A00991-1. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00991-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Syndecan 1 is a protein which in humans is encoded by the SDC1 gene. The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.

Synonyms

Syndecan-1; SYND1; CD138; SDC1; SDC

Gene Name

SDC1

Gene ID

6382

UniProt

P18827

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Syndecan-1/SDC1 recombinant protein (Position: Q23-G254) . Human Syndecan-1/SDC1 shares 69.2% and 69.8% amino acid (aa) sequence identity with mouse and rat Syndecan-1/SDC1, respectively.

Clonality

Polyclonal

Tissue Specificity

Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non- spherocytic hemolytic anemia of unknown etiology. .

Applications

WB

Field of Research

Cancer, Cancer Metabolism, Cell Adhesion Proteins, Cell Type Marker, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Hematopoietic Progenitors, Invasion/Microenvironment, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lymphoid, Membrane Proteins, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Neurogenesis, Neurology Process, Neuron Marker, Neuroscience, Pathways and Processes, Signal Transduction, Stem Cells, Synapse Marker

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.

References & Citations

1. Ala-Kapee M, Nevanlinna H, Mali M, Jalkanen M, Schröder J (September 1990) . Localization of gene for human syndecan, an integral membrane proteoglycan and a matrix receptor, to chromosome 2. Somat. Cell Mol. Genet.16 (5) : 501–5. 2. Mali M, Jaakkola P, Arvilommi AM, Jalkanen M (April 1990) . Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans. J. Biol. Chem. 265 (12) : 6884–9.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

32462 MW

Observed Molecular Weight

60 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Syndecan-1

Subcellular Location

Membrane; Single-pass type I membrane protein. Secreted. Shedding of the ectodomain produces a soluble form.

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.