Anti-Homeobox protein SIX6 Antibody Picoband®

About this product

Boster Bio Anti-Homeobox protein SIX6 Antibody Picoband® catalog # A06502-1. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A06502-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2) .

Synonyms

Homeobox protein SIX6; Homeodomain protein OPTX2; Optic homeobox 2; Sine oculis homeobox homolog 6; SIX6; OPTX2, SIX9

Gene Name

SIX6

Gene ID

4990

UniProt

O95475

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human SIX6 recombinant protein (Position: A188-I246) . Human SIX6 shares 91.5% amino acid (aa) sequence identity with mouse SIX6.

Clonality

Polyclonal

Tissue Specificity

Expressed in the developing and adult retina. Also expressed in the hypothalamic and the pituitary regions.

Applications

WB

Field of Research

Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Neuroscience, Sensory System, Transcription, Visual System

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

May be involved in eye development.

References & Citations

1. Aijaz, S., Clark, B. J., Williamson, K., van Heyningen, V., Morrison, D., FitzPatrick, D., Collin, R., Ragge, N., Christoforou, A., Brown, A., Hanson, I. Absence of SIX6 mutations in microphthalmia, anophthalmia, and coloboma. Invest. Ophthal. Vis. Sci. 45: 3871-3876, 2004. 2. Aldahmesh, M. A., Khan, A. O., Hijazi, H., Alkuraya, F. S. Homozygous truncation of SIX6causes complex microphthalmia in humans. (Letter) Clin. Genet. 84: 198-199, 2013. 3. Gallardo, M. E., Rodriguez de Cordoba, S., Schneider, A. S., Dwyer, M. A., Ayuso, C., Bovolenta, P. Analysis of the developmental SIX6 homeobox gene in patients with anophthalmia/microphthalmia. (Letter) Am. J. Med. Genet. 129A: 92-94, 2004.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

27687 MW

Observed Molecular Weight

28 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Homeobox protein SIX6

Subcellular Location

Nucleus .

Isotype

Rabbit IgG

Contents

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