Anti-CHX10/VSX2 Antibody Picoband®

About this product

Boster Bio Anti-CHX10/VSX2 Antibody Picoband® catalog # A05180. Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A05180

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Visual system homeobox 2 is a protein that in humans is encoded by the VSX2 gene. This gene encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities. In situ hybridization to human fetal retinal sections detected CHX10 expression in retinal neuroblasts at all stages examined. Human CHX10 is expressed in progenitor cells of the developing neuroretina and in the inner nuclear layer of the mature retina.

Synonyms

Visual system homeobox 2; Ceh-10 homeodomain-containing homolog; Homeobox protein CHX10; VSX2; CHX10, HOX10

Gene Name

VSX2

Gene ID

338917

UniProt

P58304

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human CHX10 recombinant protein (Position: A249-A361) . Human CHX10 shares 90.3% amino acid (aa) sequence identity with mouse CHX10.

Clonality

Polyclonal

Tissue Specificity

Abundantly expressed in retinal neuroblasts during eye development and in the inner nuclear layer of the adult retina. Within this layer, expression is stronger in the outer margin where bipolar cells predominate.

Applications

WB

Field of Research

2339, Epigenetics and Nuclear Signaling, Neurogenesis, Neurology Process, Neuroscience, Sensory System, Visual System

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity) . .

References & Citations

1. McInnes, R. R., Basu, S., Novak, J., Ploder, L., Liang, M.-Y., Hawes, N., Taylor, B., Roderick, T., Goldman, D., Hankin, M., Burmeister, M. The ocular retardation (orJ) mouse has an ochre mutation in the homeobox gene Chx10: evidence for Chx10 as a major determinant of retinal development. (Abstract) Am. J. Hum. Genet. 55 (suppl.) : A3, 1994. 2. Reichman, S., Kalathur, R. K. R., Lambard, S., Ait-Ali, N., Yang, Y., Lardenois, A., Ripp, R., Poch, O., Zack, D. J., Sahel, J.-A., Leveillard, T. The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina. Hum. Molec. Genet. 19: 250-261, 2010.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

39411 MW

Observed Molecular Weight

43 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Visual system homeobox 2

Subcellular Location

Nucleus.

Protein Name

Long-chain-fatty-acid--CoA ligase 5

Isotype

Rabbit IgG

Contents

243