Anti-Factor D/Cfd Antibody Picoband®

About this product

Boster Bio Anti-Factor D/Cfd Antibody Picoband® catalog # A01134-2. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01134-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Factor D is a protein which in humans is encoded by the CFD gene. The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. It is also a serine protease that is secreted by adipocytes into the bloodstream. And it stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.

Synonyms

Complement factor D; Adipsin; C3 convertase activator; Endogenous vascular elastase; Properdin factor D; Cfd; Adn; Df

Gene Name

Cfd

Gene ID

54249

UniProt

P32038

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived rat Factor D recombinant protein (Position: I26-A263) . Mouse Factor D shares 69% and 84.5% amino acid (aa) sequence identity with human and rat Factor D, respectively.

Clonality

Polyclonal

Applications

ELISA, IHC, WB

Field of Research

Mesenchymal Stem Cells, Stem Cells

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

References & Citations

1. Biesma, D. H., Hannema, A. J., van Velzen-Blad, H., Mulder, L., van Zwieten, R., Kluijt, I., Roos, D. A family with complement factor D deficiency. J. Clin. Invest. 108: 233-240, 2001. 2. Ronti T, Lupattelli G, Mannarino E (April 2006) . The endocrine function of adipose tissue: an update. Clin. Endocrinol. (Oxf) 64 (4) : 355–65. 3. Volanakis JE, Narayana SV (April 1996) . Complement factor D, a novel serine protease. Protein Sci. 5 (4) : 553–64.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

27 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Complement factor D (adipsin)

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

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