Anti-Psoriasin/S100A7 Antibody Picoband®

About this product

Boster Bio Anti-Psoriasin/S100A7 Antibody Picoband® catalog # A02369-1. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02369-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

S100 calcium-binding protein A7 (S100A7), also known as psoriasin, is a protein that in humans is encoded by the S100A7 gene. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities.

Synonyms

Protein S100-A7; Psoriasin; S100 calcium-binding protein A7; S100A7; PSOR1, S100A7C

Gene Name

S100A7

Gene ID

6278

UniProt

P31151

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Psoriasin recombinant protein (Position: S2-Q101) .

Clonality

Polyclonal

Tissue Specificity

Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients. .

Applications

ELISA, Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Calcium Binding Proteins, Calcium Signaling, Neuroscience, Neurotransmission

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

References & Citations

1. Entrez Gene: S100A7 S100 calcium binding protein A7. 2. Winston J, Wolf R (September 2012) . Psoriasin (S100A7) promotes migration of a squamous carcinoma cell line. J. Dermatol. Sci. 67 (3) : 205–7.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

11471 MW

Observed Molecular Weight

17 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Protein S100-A7

Subcellular Location

Cytoplasm . Secreted . Secreted by a non- classical secretory pathway.

Protein Name

Neuronal acetylcholine receptor subunit alpha-5

Isotype

Rabbit IgG

Contents

243