Anti-TL1A/TNFSF15 Antibody Picoband®

About this product

Boster Bio Anti-TL1A/TNFSF15 Antibody Picoband® catalog # A02402-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02402-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Vascular endothelial growth inhibitor (VEGI), also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15 (TNFSF15), is protein that in humans is encoded by the TNFSF15 gene. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms

Tumor necrosis factor ligand superfamily member 15; TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitor; Tumor necrosis factor ligand superfamily member 15; membrane form; Tumor necrosis factor ligand superfamily member 15; secreted form; TNFSF15; TL1; VEGI

Gene Name

TNFSF15

Gene ID

9966

UniProt

O95150

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human TL1A recombinant protein (Position: L72-T244) .

Clonality

Polyclonal

Tissue Specificity

Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.

Applications

ELISA (Cap), IHC, WB

Field of Research

Angiogenesis, Cardiovascular, Cytokines, Immunology, Innate Immunity, TNF Superfamily

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro) . Promotes activation of caspases and apoptosis.

References & Citations

1. Entrez Gene: TNFSF15 tumor necrosis factor (ligand) superfamily, member 15. 2. Picornell Y, Mei L, Taylor K, Yang H, Targan SR, Rotter JI (Nov 2007) . TNFSF15 is an ethnic-specific IBD gene. Inflammatory Bowel Diseases. 13 (11) : 1333–8.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

28 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

TNF superfamily member 15

Subcellular Location

Membrane.

Isotype

Rabbit IgG

Contents

243