Anti-Serum Amyloid P/APCS Antibody Picoband®

About this product

Boster Bio Anti-Serum Amyloid P/APCS Antibody Picoband® catalog # A00162. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00162

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Amyloid P component, serum (SAP), also known as PTX2 or APCS, is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called amyloid. It belongs to the pentraxins family, characterised by calcium dependent ligand binding and distinctive flattened β -jellyroll structure similar to that of the legume lectins. This gene is mapped to 1q23.2. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.

Synonyms

Serum amyloid P-component; SAP; 9.5S alpha-1-glycoprotein; Serum amyloid P-component (1-203) ; APCS; PTX2

Gene Name

APCS

Gene ID

325

UniProt

P02743

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Serum Amyloid P recombinant protein (Position: H20-L220) .

Clonality

Polyclonal

Tissue Specificity

Found in serum and urine.

Applications

ELISA, Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Atherosclerosis, Cancer, Cardiovascular, Chemokines, G Protein Signaling, Host-Virus Interaction, Immunology, Innate Immunity, Interspecies Interaction, Macrophage/Inflammation, Microbiology, Nuclear Signaling, Signal Transduction, Signaling Pathway, Vascular Inflammation

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

References & Citations

1. Cathcart ES, Shirahama T, Cohen AS (1967) . Isolation and identification of a plasma component of amyloid. Biochim. Biophy. Acta 147: 392–393. 2. Entrez Gene: APCS amyloid P component, serum. 3. Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP (1994) . Structure of pentameric human serum amyloid P component. Nature 367 (6461) : 338–45.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

25-29 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Amyloid P component, serum

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.