Anti-CRLF2 Antibody Picoband®

About this product

Boster Bio Anti-CRLF2 Antibody Picoband® catalog # A04167-1. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A04167-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cytokine receptor-like factor 2 is a protein that in humans is encoded by the CRLF2 gene. This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP) . Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.

Synonyms

Cytokine receptor-like factor 2; Cytokine receptor-like 2; IL-XR; Thymic stromal lymphopoietin protein receptor; TSLP receptor; CRLF2; CRL2; ILXR; TSLPR

Gene Name

CRLF2

Gene ID

64109

UniProt

Q9HC73

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human CRLF2 recombinant protein (Position: A26-K231) .

Clonality

Polyclonal

Tissue Specificity

Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells.

Applications

ELISA (Cap), WB

Field of Research

Cytokines, Immunology, Innate Immunity

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for thymic stromal lymphopoietin (TSLP) . Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity) . Implicated in the development of the hematopoietic system.

References & Citations

1. Entrez Gene: CRLF2 cytokine receptor-like factor 2. 2. Tonozuka Y, Fujio K, Sugiyama T, Nosaka T, Hirai M, Kitamura T (Jul 2001) . Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR. Cytogenet Cell Genet. 93 (1–2) : 23–5. 3. Zhang W, Wang J, Wang Q, Chen G, Zhang J, Chen T, Wan T, Zhang Y, Cao X (Mar 2001) . Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes. Biochem Biophys Res Commun. 281 (4) : 878–83.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

65-75 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Cytokine receptor like factor 2

Subcellular Location

Isoform 1: Cell membrane ; Single-pass type I membrane protein.

Isotype

Rabbit IgG

Contents

243