Anti-COL18A1 Antibody Picoband®

About this product

Boster Bio Anti-COL18A1 Antibody Picoband® catalog # A01302-1. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01302-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Collagen alpha-1 (XVIII) chain is a protein that in humans is encoded by the COL18A1 gene. This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.

Synonyms

Collagen alpha-1 (XVIII) chain; Endostatin; COL18A1

Gene Name

COL18A1

Gene ID

80781

UniProt

P39060

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human COL18A1 recombinant protein (Position: H1572-K1754) .

Clonality

Polyclonal

Tissue Specificity

Present in multiple organs with highest levels in liver, lung and kidney.

Applications

WB

Field of Research

Angiogenesis, Cancer, Cardiovascular, Collagen, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Invasion/Microenvironment, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.

References & Citations

1. Entrez Gene: COL18A1 collagen, type XVIII, alpha 1. 2. Oh SP, Warman ML, Seldin MF, Cheng SD, Knoll JH, Timmons S, Olsen BR (Jun 1994) . Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1 (XVIII) collagen gene to mouse chromosome 10 and human chromosome 21. Genomics. 19 (3) : 494–9.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

180 kDa, 20 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Collagen, type XVIII, alpha 1

Subcellular Location

Secreted, extracellular space, extracellular matrix.

Isotype

Rabbit IgG

Contents

243