Anti-MYBPC3 Antibody Picoband®

About this product

Boster Bio Anti-MYBPC3 Antibody Picoband® catalog # A01078-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01078-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

The myosin-binding protein C, cardiac-type is a protein that in humans is encode by the MYBPC3 gene. MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.

Synonyms

Myosin-binding protein C, cardiac-type; Cardiac MyBP-C; C-protein, cardiac muscle isoform; MYBPC3

Gene Name

MYBPC3

Gene ID

4607

UniProt

Q14896

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human MYBPC3 recombinant protein (Position: Q1070-H1123) .

Clonality

Polyclonal

Tissue Specificity

Red blood cells.

Applications

ELISA, IHC, WB

Field of Research

Cardiovascular, Contractility, Hypertrophy

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.

References & Citations

1. Calore, C., De Bortoli, M., Romualdi, C., Lorenzon, A., Angelini, A., Basso, C., Thiene, G., Iliceto, S., Rampazzo, A., Melacini, P. A founder MYBPC3 mutation results in HCM with a high risk of sudden death after the fourth decade of life. J. Med. Genet. 52: 338-347, 2015. 2. Ehlermann, P., Weichenhan, D., Zehelein, J., Steen, H., Pribe, R., Zeller, R., Lehrke, S., Zugck, C., Ivandic, B. T., Katus, H. A. Adverse events in families with hypertrophic or dilated cardiomyopathy and mutations in the MYBPC3 gene. BMC Med. Genet. 9: 95, 2008.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

160 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Myosin binding protein C, cardiac

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.