Anti-Synaptotagmin 1/SYT1 Antibody Picoband®

About this product

Boster Bio Anti-Synaptotagmin 1/SYT1 Antibody Picoband® catalog # A02314-1. Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02314-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene. The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca (2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse.

Synonyms

Synaptotagmin-1; Synaptotagmin I; SytI; p65; SYT1; SVP65; SYT

Gene Name

SYT1

Gene ID

6857

UniProt

P21579

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Synaptotagmin 1, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed in melanocytes (PubMed:23999003) .

Applications

Flow Cytometry, IHC, ICC, WB

Field of Research

Neuroscience, Neurotransmission, Protein Trafficking, Secretory Vesicles, Signal Transduction, Vesicle Transport

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca (2+) -dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca (2+) -independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003) .

References & Citations

1. Fernandez-Chacon, R., Konigstorfer, A., Gerber, S. H., Garcia, J., Matos, M. F., Stevens, C. F., Brose, N., Rizo, J., Rosenmund, C., Sudhof, T. C. Synaptotagmin I functions as a calcium regulator of release probability. Nature 410: 41-49, 2001. 2. Poskanzer, K. E., Marek, K. W., Sweeney, S. T., Davis, G. W. Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo. Nature 426: 559-563, 2003.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

33927 MW

Observed Molecular Weight

65 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Synaptotagmin 1

Subcellular Location

Cytoplasmic vesicle, secretory vesicle membrane.

Protein Name

Adrenocorticotropic hormone receptor

Isotype

Rabbit IgG

Contents

243