Anti-TBR2/Eomes Antibody Picoband®

About this product

Boster Bio Anti-TBR2/Eomes Antibody Picoband® catalog # A00992-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00992-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Eomesodermin also known as T-box brain protein 2 (Tbr2) is a protein that in humans is encoded by the EOMES gene. This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants.

Synonyms

Eomesodermin homolog; T-box brain protein 2; T-brain-2; TBR-2; EOMES; TBR2

Gene Name

EOMES

Gene ID

8320

UniProt

O95936

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human TBR2/Eomes recombinant protein (Position: T310-D532) .

Clonality

Polyclonal

Tissue Specificity

Expressed in CD8+ T-cells.

Applications

WB, ELISA

Field of Research

Cell Type Marker,2339, Developmental Biology, Epigenetics and Nuclear Signaling, Germ Cell Markers, Germline Stem Cells, Intracellular, Lineage Specification, Neural Signal Transduction, Neural Stem Cells, Neurogenesis, Neurology Process, Neuron Marker, Neuroscience, Reproduction, Stem Cells

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.

References & Citations

1. Arnold SJ, Huang GJ, Cheung AF, Era T, Nishikawa S, Bikoff EK, Molnár Z, Robertson EJ, Groszer M (2008) . The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. Genes & Development. 22 (18) : 2479–84. 2. Sessa A, Mao CA, Hadjantonakis AK, Klein WH, Broccoli V (Oct 2008) . Tbr2 s conversion of radial glia into basal precursors and guides neuronal amplification by in neurogenesis in the developing neocortex glish. Neuron. 60 (1) : 56–69.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

32462 MW

Observed Molecular Weight

85 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Eomesodermin

Subcellular Location

Nucleus.

Isotype

Rabbit IgG

Contents

243