Anti-Neurexin 1/NRXN1 Antibody Picoband®

About this product

Boster Bio Anti-Neurexin 1/NRXN1 Antibody Picoband® catalog # A01490-1. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01490-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene. This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca (2+) -dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.

Synonyms

Neurexin-1-beta; Neurexin I-beta; NRXN1

Gene Name

NRXN1

Gene ID

9378

UniProt

P58400

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Neurexin 1 recombinant protein (Position: D141-E294) .

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in the liver (PubMed:11099417, PubMed:11452359) . Low expression levels in the small intestine and colon (PubMed:11099417) . Very low levels in other tissues, including brain, heart and spleen (PubMed:11452359) .

Applications

ELISA, Flow Cytometry, WB

Field of Research

Adapters, Axonal Guidance Proteins, Cell Adhesion Proteins, Cell Type Marker, Growth and Development, Membrane Proteins, Neurology Process, Neuron Marker, Neuroscience, Signal Transduction, Synapse Marker, Transmembrane

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity) . .

References & Citations

1. Comoletti, Davide; Flynn Robyn; Jennings Lori L; Chubykin Alexander; Matsumura Takehito; Hasegawa Hana; Südhof Thomas C; Taylor Palmer (Dec 2003) . Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta. J. Biol. Chem. United States. 278 (50) : 50497–50505. 2. Nguyen T, Südhof TC (1997) . Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules. J. Biol. Chem. 272 (41) : 26032–26039.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

75679 MW

Observed Molecular Weight

160-170 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Neurexin 1

Subcellular Location

Cell membrane; Localized on the pre- synaptic membrane.

Protein Name

ATP-binding cassette sub-family G member 8

Isotype

Rabbit IgG

Contents

243