- Catalog number
- A02952-1
- Size / count
- 100 µg/Vial
- Dry ice
- No
- Hazardous
- No
- Discontinued
- No
- Background
- Transmembrane activator and CAML interactor (TACI), also known as tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) is a protein that in humans is encoded by the TNFRSF13B gene. The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML) . The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17.
- Synonyms
- Tumor necrosis factor receptor superfamily member 13B; Transmembrane activator and CAML interactor; CD267; TNFRSF13B; TACI
- Gene Name
- TNFRSF13B
- Gene ID
- 23495
- UniProt
- O14836
- Host
- Rabbit
- Reactivity
- Human
- Cross Reactivity
- No cross-reactivity with other proteins.
- Immunogen
- E. coli-derived human TACI recombinant protein (Position: M1-S165) .
- Clonality
- Polyclonal
- Tissue Specificity
- Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B- cells and activated T-cells, but not in resting T-cells.
- Applications
- IHC
- Field of Research
- Apoptosis, Apoptotic Markers, Cancer, Caspases, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes
- Purification
- Immunogen affinity purified.
- Concentration
- Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
- Form
- Lyophilized
- Reconstitution
- Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
- Function
- Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T- cell function and the regulation of humoral immunity.
- References & Citations
- 1. Entrez Gene: TNFRSF13B tumor necrosis factor receptor superfamily, member 13B. 2. Seshasayee D, Valdez P, Yan M, Dixit VM, Tumas D, Grewal IS (February 2003) . Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. Immunity. 18 (2) : 279–88.
- Storage Conditions
- Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
- Calculated Molecular Weight
- 79686 MW
- Observed Molecular Weight
- 40 kDa
- Specificity
- No cross reactivity with other proteins.
- Gene Name Synonym
- TNF receptor superfamily member 13B
- Subcellular Location
- Membrane; Single-pass type III membrane protein.
- Protein Name
- Peroxisomal multifunctional enzyme type 2
- Isotype
- Rabbit IgG
- Contents
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
