Anti-BCMA/TNFRSF17 Antibody Picoband®

About this product

Boster Bio Anti-BCMA/TNFRSF17 Antibody Picoband® catalog # A01014-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01014-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.

Synonyms

Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269; TNFRSF17; BCM; BCMA

Gene Name

TNFRSF17

Gene ID

608

UniProt

Q02223

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human BCMA recombinant protein (Position: M1-A54) .

Clonality

Polyclonal

Tissue Specificity

Expressed in mature B-cells, but not in T- cells or monocytes.

Applications

ELISA (Cap), IHC, WB

Field of Research

Antiviral Signaling, Cancer, Growth Factors, Growth Factors/Hormones, Immune System Diseases, Immunology, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

References & Citations

1. Entrez Gene: TNFRSF17 tumor necrosis factor receptor superfamily, member 17. 2. Laabi Y, Gras MP, Brouet JC, Berger R, Larsen CJ, Tsapis A (Apr 1994) . The BCMA gene, preferentially expressed during B lymphoid maturation, is biionally transcribed. Nucleic Acids Research. 22 (7) : 1147–54.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

63173 MW

Observed Molecular Weight

20 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

TNF receptor superfamily member 17

Subcellular Location

Cell membrane; Perinuclear Golgi-like structures.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.