Anti-Cathepsin E/CTSE Antibody Picoband®

About this product

Boster Bio Anti-Cathepsin E/CTSE Antibody Picoband® catalog # A04874-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A04874-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cathepsin E is an enzyme that in humans is encoded by the CTSE gene. This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration.

Synonyms

Cathepsin E; Cathepsin E form I; Cathepsin E form II; CTSE

Gene Name

CTSE

Gene ID

1510

UniProt

P14091

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Cathepsin E recombinant protein (Position: A150-R393) .

Clonality

Polyclonal

Tissue Specificity

Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B- lymphocytes.

Applications

IHC, WB

Field of Research

Adaptive Immunity, Immunology, Innate Immunity, Macrophage/Inflammation

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.

References & Citations

1. Azuma T, Pals G, Mohandas TK, Couvreur JM, Taggart RT (October 1989) . Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases. The Journal of Biological Chemistry. 264 (28) : 16748–53. 2. Couvreur JM, Azuma T, Miller DA, Rocchi M, Mohandas TK, Boudi FA, Taggart RT (Aug 1990) . Assignment of cathepsin E (CTSE) to human chromosome region 1q31 by in situ hybridization and analysis of somatic cell hybrids. Cytogenetics and Cell Genetics. 53 (2-3) : 137–9.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

35883 MW

Observed Molecular Weight

48 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Cathepsin E

Subcellular Location

Endosome.

Protein Name

Annexin A4

Isotype

Rabbit IgG

Contents

243