Anti-ANP/Nppa Antibody Picoband®

About this product

Boster Bio Anti-ANP/Nppa Antibody Picoband® catalog # A01318. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01318

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Atrial natriuretic peptide (ANP), also known as NPPA or PND, is a powerful vasodilator, and a protein (polypeptide) hormone secreted by heart muscle cells. This gene is mapped to 1p36.22. It is involved in the homeostatic control of body water, sodium, potassium and fat (adipose tissue) . ANP is released by muscle cells in the upper chambers (atria) of the heart (atrial myocytes) in response to high blood volume. It acts to reduce the water, sodium and adipose loads on the circulatory system, thereby reducing blood pressure. ANP has exactly the opposite function of the aldosterone secreted by the zona glomerulosa in regard to its effect on sodium in the kidney – that is, aldosterone stimulates sodium retention and it generates sodium loss.

Synonyms

Natriuretic peptides A; Prepronatriodilatin; Atrial natriuretic factor; ANF; Atrial natriuretic peptide; ANP; Auriculin-B; Auriculin-A; Atriopeptin-1; Atriopeptin I; Atriopeptin-2; Atriopeptin II; Nppa; Pnd

Gene Name

Nppa

Gene ID

230899

UniProt

P05125

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived mouse ANP recombinant protein (Position: N25-R122) .

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.

Applications

ELISA, IHC, WB

Field of Research

Cardiovascular

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

References & Citations

1. Addicks K, Forssmann WG, Henkel H, Holthausen U, Menz V, Rippegather G, Ziskoven D (1989) . Calcium-calmodulin antagonists Influences the release of cardiodilatin/ANP from atrial cardiocytes. In Wambach G, Kaufmann W.Endocrinology of the heart. Berlin: Springer-Verlag. 1. 2. Potter LR, Yoder AR, Flora DR, Antos LK, Dickey DM (2009) . Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications. Handb Exp Pharmacol. Handbook of Experimental Pharmacology 191 (191) : 341–66. 3. Widmaier, Eric P.; Hershel Raff; Kevin T. Strang (2008) . Vander's Human Physiology, 11th Ed. McGraw-Hill. pp. 291, 509–10.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

60066 MW

Observed Molecular Weight

17 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Natriuretic peptide type A

Subcellular Location

Secreted.

Protein Name

Heparanase

Isotype

Rabbit IgG

Contents

243