Anti-SPARCL1 Antibody Picoband®

About this product

Boster Bio Anti-SPARCL1 Antibody Picoband® catalog # A05726. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A05726

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

SPARCL1 (SPARC-Like Protein 1), also known as HEVIN, is a protein that in humans is encoded by the SPARCL1 gene. The cells in high endothelial venules (HEVs) in lymphoid tissues have a plump, almost cuboidal, appearance and support high levels of lymphocyte extravasation from blood, possibly due to the presence of desmosome-like junctions rather than tight junctions in the HEVs. In chronic inflammation, the activated endothelium of nonlymphoid tissues acquires an HEV-like morphology and function. Hevin is highly expressed in HEV and is thought to contribute to the induction or maintenance of features of the HEV endothelium that facilitate lymphocyte migration.

Synonyms

SPARC-like protein 1; High endothelial venule protein; Hevin; MAST 9; SPARCL1

Gene Name

SPARCL1

Gene ID

8404

UniProt

Q14515

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human SPARCL1, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and peripheral blood leukocytes.

Applications

IHC, WB

Field of Research

Cancer, Oncoproteins/Suppressors, Tumor Biomarkers, Tumor Suppressors

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA) . Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.

References & Citations

1. Girard, J.-P., Springer, T. A. Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC. Immunity 2: 113-123, 1995.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

101272 MW

Observed Molecular Weight

62 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

SPARC-like 1 (hevin)

Subcellular Location

Secreted, extracellular space, extracellular matrix.

Protein Name

N-alpha-acetyltransferase 15, NatA auxiliary subunit

Isotype

Rabbit IgG

Contents

243