Anti-Talin 1/TLN1 Antibody Picoband®

About this product

Boster Bio Anti-Talin 1/TLN1 Antibody Picoband® catalog # A02859-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02859-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Talin-1 is a protein that in humans is encoded by the TLN1 gene. This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.

Synonyms

Talin-1; TLN1; KIAA1027; TLN

Gene Name

TLN1

Gene ID

7094

UniProt

Q9Y490

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human Talin 1, which shares 97.6% amino acid (aa) sequence identity with both mouse and rat Talin 1.

Clonality

Polyclonal

Tissue Specificity

Placenta and skin. Predominantly expressed in mammary gland tissue.

Applications

IHC, WB

Field of Research

Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity) .

References & Citations

1. Ben-Yosef T, Francomano CA (Dec 1999) . Characterization of the human talin (TLN) gene: genomic structure, chromosomal localization, and expression pattern. Genomics. 62 (2) : 316–9. 2. Gilmore AP, Ohanian V, Spurr NK, Critchley DR (Aug 1995) . Localisation of the human gene encoding the cytoskeletal protein talin to chromosome 9p. Human Genetics. 96 (2) : 221–4.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

36043 MW

Observed Molecular Weight

270 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Talin 1

Subcellular Location

Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell surface.

Protein Name

Melanocortin receptor 3

Isotype

Rabbit IgG

Contents

243