Anti-HE4/WFDC2 Antibody Picoband®

About this product

Boster Bio Anti-HE4/WFDC2 Antibody Picoband® catalog # A02685-4. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02685-4

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

WAP four-disulfide core domain protein 2, also known as Human Epididymis Protein 4 (HE4), is a protein that in humans is encoded by the WFDC2 gene. This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.

Synonyms

WAP four-disulfide core domain protein 2; Epididymal secretory protein E4; Major epididymis-specific protein E4; Putative protease inhibitor WAP5; WFDC2; HE4; WAP5

Gene Name

WFDC2

Gene ID

10406

UniProt

Q14508

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human HE4 recombinant protein (Position: E31-F124) .

Clonality

Polyclonal

Applications

ELISA, IHC, WB

Field of Research

Cell Type Markers, Tags & Cell Markers, Tumor Associated

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Broad range protease inhibitor.

References & Citations

1. Entrez Gene: WFDC2 WAP four-disulfide core domain 2. 2. Hellström I, Raycraft J, Hayden-Ledbetter M, Ledbetter JA, Schummer M, McIntosh M, Drescher C, Urban N, Hellström KE (2003-07-01) . The HE4 (WFDC2) Protein Is a Biomarker for Ovarian Carcinoma. Cancer Research63 (13) : 3695–3700. 3. Molina R, Escudero JM, Augé JM, Filella X, Foj L, Torné A, Lejarcegui J, Pahisa J (2011) . HE4 a novel tumour marker for ovarian cancer: Comparison with CA 125 and ROMA algorithm in patients with gynaecological diseases. Tumor Biology 32 (6) : 1087–95.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

15 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

WAP four-disulfide core domain 2

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

243